(2003). Likelihood Ratio and Score Tests for Heterogeneity in Genetic Linkage. The Egyptian Statistical Journal, 47(1), 11-35. doi: 10.21608/esju.2003.313775
. "Likelihood Ratio and Score Tests for Heterogeneity in Genetic Linkage". The Egyptian Statistical Journal, 47, 1, 2003, 11-35. doi: 10.21608/esju.2003.313775
(2003). 'Likelihood Ratio and Score Tests for Heterogeneity in Genetic Linkage', The Egyptian Statistical Journal, 47(1), pp. 11-35. doi: 10.21608/esju.2003.313775
Likelihood Ratio and Score Tests for Heterogeneity in Genetic Linkage. The Egyptian Statistical Journal, 2003; 47(1): 11-35. doi: 10.21608/esju.2003.313775
Likelihood Ratio and Score Tests for Heterogeneity in Genetic Linkage
One of the fundamental goals of most linkage studies is to localize a gene believed to be responsible for a trait locus by the investigation of its co-segregation with a genetic marker. Statistical techniques for linkage investigations have been introduced in the early 1930's. These were followed by the introduction of the log-odds approach (Morton 1955; Smith 1963) which provided standard methods to report and analyze linkage data collected from independent sib-ships. Because of the heterogeneity in the manner diseases affect families, use of the standard log-odds approach will result in a considerable reduction i the statistical power to detect linkage between disease trait and marker loci. This paper investigates the asymptotic properties of statistical tests that would be used to detect linkage under heterogeneity.
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